Outcomes

 

Non small cell

Small cell


Long term survival in patients with non small cell

 

STAGE 5 YEAR SURVIVAL % Note
     
1A    T1N0 80  1
1B     T2N0 50 1
IIA    (T1N1M0) & IIB (T2N1M0, T3N0M0) 25-30 2
IIIA    T3N1M0, T(1–3)N2M0 10 3
IIIB    T4, Any N, M0 Any T, N3M0 <10 4
IV      Any T, Any N, M1 <5 5

 

Notes:

1 Results of squamous better than adenocarcinoma. No adjuvant therapy shown to be of benefit. 10 to 15% will develop second primary.

2 No difference in survival between cell types. Adjuvant therapy reduces local recurrence , but has no effect on long term survival. Most relapses due to systemic metastasis.

3 Completely resected T3N1 better than N2 disease 30-40 % verses 10-40 %. No difference in survival between cell types. Induction therapy resulting in no tumour being found in surgical specimen probably have better prognosis. 

4 Concurrent chemotherapy and radiotherapy prolongs median survival by months in good performance patients, though usually aimed at palliating symptoms.

5 All therapies palliative. If no symptoms no therapy acceptable.


 

Small cell survival

1 Extensive disease <5 % 5 year survival. Median survival 8-12 months.

2 Limited disease <20 % 5 year survival. Median survival 12-15 months.

3 Very limited disease ~25 % 5 year survival. Includes unusual patients with resected stage 1.